歡迎光臨 王東弘 老師個人學術研究網頁 |
基本資料
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所屬系所:
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健康產業科技研究所 健康產業科技研究所教研會 兼任 教授 ( 林口校區 )
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英文姓名:
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Wang,Tong-Hong
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最高學歷:
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陽明大學 醫學生物技術研究所 博士
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辦公室:
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林口長庚醫院組織銀行
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聯絡電話:
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(03)211-8999#7713
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電子郵件:
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cellww@cgmh.org.tw
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專長領域:
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分子生物學 細胞生物學
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研究興趣:
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肝癌致病機轉 non-coding RNA於生理調控之角色
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實務經驗列表
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相關證照列表
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專業服務列表
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年度 | 案號 | 案名 | 校內/校外 | 服務廠商 | 服務性質 | 生效日期 | 終止日期 |
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學術活動列表
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年度 | 活動名稱/進修課程 | 主辦單位/進修機構 | 活動種類 | 活動型態 | 活動地點 | 參與情形 | 開始日期 | 結束/完成日期 | 時數 |
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承接計畫案列表
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年度 | 案名 | 類型 | 起始日期 | 結束日期 | 工作類別 |
104 | 可應用於肝癌診斷與治療之新穎長片段非編碼RNA及其調控機制 | 國科會專題研究計畫(D1) | 2015/08/01 | 2016/07/31 | 主持人 |
105 | 可應用於肝癌診斷與治療之新穎長片段非編碼RNA及其調控機制(II) | 國科會專題研究計畫(D1) | 2016/08/01 | 2017/07/31 | 主持人 |
106 | 褪黑激素應用於肝癌治療及其調控機制 (專注於長非編碼RNA的探討) | 國科會專題研究計畫(D1) | 2017/08/01 | 2018/07/31 | 主持人 |
107 | 褪黑激素應用於肝癌治療及其調控機制 (專注於長非編碼RNA的探討) | 國科會專題研究計畫(D1) | 2018/08/01 | 2021/07/31 | 主持人 |
107 | 應用羥基芫花素於肝癌治療及其機制探討 | 企業其他案件(G1) | 2019/07/01 | 2020/06/30 | 主持人 |
107 | 應用補骨脂寧於肝癌及肝纖維化治療及其機制探討 | 企業其他案件(G1) | 2019/07/01 | 2022/06/30 | 主持人 |
108 | 應用羥基芫花素於肝癌治療及其機制探討 | 企業其他案件(G1) | 2020/07/01 | 2021/06/30 | 主持人 |
期刊論文列表
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( 點選資料列,即可瀏覽更詳細的內容! ) |
年度 | 所屬計畫案 | 論文名稱 | 收錄分類 | 作者順序 | 通訊作者 | 刊物名稱 | 發表卷數 | 發表期數 | 發表月份 | 發表年份 |
104 | CMRPG3A1193 | Automated biphasic morphological assessment of hepatitis B-related liver fibrosis using second harmonic generation microscopy. | SCI | 第一作者 | 否 | Scientific Reports | 5 | 5 | 08 | 2015 |
104 | NSC 103-2320-B-182A-003- | Long non-coding RNA AOC4P suppresses hepatocellular carcinoma metastasis by enhancing vimentin degradation and inhibiting epithelial-mesenchymal transition. | SCI | 第一作者 | 否 | Oncotarget | 6 | 27 | 09 | 2015 |
104 | NSC 103-2320-B-182A-003- | OncomiR miR-96 and miR-182 promote cell proliferation and invasion through targeting ephrinA5 in hepatocellular carcinoma. | SCI | 第一作者 | 否 | molecular carcinogenesis | 55 | 4 | 04 | 2016 |
104 | 無 | Isoliquiritigenin as a cause of DNA damage and inhibitor of ataxia-telangiectasia mutated expression leading to G2/M phase arrest and apoptosis in oral squamous cell carcinoma. | SCI | 第五作者 | 否 | Head & Neck | 38 | 1 | 04 | 2016 |
104 | 無 | HBV polymerase overexpression due to large core gene deletion enhances hepatoma cell growth by binding inhibition of microRNA-100 | SCI | 第六作者 | 否 | Oncotarget | 7 | 8 | 02 | 2016 |
104 | 無 | Heterogeneous nuclear ribonucleoproteins A1 and A2 modulate expression of Tid1 isoforms and EGFR signaling in non-small cell lung cancer. | SCI | 第六作者 | 否 | Oncotarget | 7 | 13 | 03 | 2016 |
104 | MOST 104-2320-B-182A-009- | Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition. | SCI | 第一作者 | 否 | Oncotarget | 7 | 28 | 07 | 2016 |
105 | 無 | Reduced miR-550a-3p leads to breast cancer initiation, growth, and metastasis by increasing levels of ERK1 and 2 | SCI | 第六作者 | 否 | Oncotarget | 7 | 33 | 08 | 2016 |
105 | 無 | Evaluation of the Antibacterial Potential of Liquid and Vapor Phase Phenolic Essential Oil Compounds against Oral Microorganisms | SCI | 第一作者 | 否 | PLOS ONE | 11 | 9 | 09 | 2016 |
105 | MOST 105-2320-B-182A-004- | Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation | SCI | 第一作者 | 否 | Oncotarget | 8 | 3 | 01 | 2017 |
105 | 無 | Pleomorphic mantle cell lymphoma morphologically mimicking diffuse large B-cell lymphoma: common cyclin D1 negativity and a simple immunohistochemical algorithm to avoid the diagnostic pitfall. | SCI | 第六作者 | 否 | Histopathology | 1 | 1 | 12 | 2016 |
105 | 無 | Lysyl Oxidase and the Tumor Microenvironment | SCI | 第一作者 | 否 | International Journal of Molecular Sciences | 18 | 1 | 12 | 2016 |
105 | CMRPG3E0341 | Platelet counts modulate the quantitative relationship between hepatitis B viral DNA and surface antigen concentrations: a cross-sectional study of hematological, histological and viral factors. | SCI | 第四作者 | 否 | BMC Infectious Diseases | 17 | 9 | 01 | 2017 |
105 | MOST 105-2320-B-182A-004- | 2-O-Methylmagnolol upregulates the long non-coding RNA, GAS5, and enhances apoptosis in skin cancer cells | SCI | 第一作者 | 否 | Cell Death and Disease | 8 | 3 | 03 | 2017 |
105 | MOST 103-2313-B-038-003-MY3 | Association of Smoking, Alcohol Use, and Betel Quid Chewing with Epigenetic Aberrations in Cancers | SCI | 第一作者 | 是 | International Journal of Molecular Sciences | 6 | 18 | 06 | 2017 |
105 | (NSC 102-2320-B-255-001 | Tid1-S regulates the mitochondrial localization of EGFR in non-small cell lung carcinoma | SCI | 第一作者 | 否 | Oncogenesis | 7 | 6 | 07 | 2017 |
105 | MOST 105-2320-B-182A-004- | A Multivariate Evaluation of Factors Affecting the Quality of Freshly Frozen Tissue Specimens | SCI | 第一作者 | 否 | Biopreservation and Biobanking | 4 | 15 | 05 | 2017 |
106 | CMRPD3D0172 | The in vivo anti-leukemia activity of N-(1-Pyrenlyl) maleimide in a bioluminescent mouse model | SCI | 第三作者 | 否 | Leukemia Research | 62 | 62 | 09 | 2017 |
106 | MOST 105-2320-B-182A-004- | Melatonin suppresses hepatocellular carcinoma progression via lncRNA-CPS1-IT-mediated HIF-1α inactivation | SCI | 第一作者 | 否 | Oncotarget | 8 | 18 | 10 | 2017 |
106 | CMRPD1F0301-3 | Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52 | SCI | 第三作者 | 否 | International Journal of Molecular Sciences | 12 | 18 | 12 | 2017 |
106 | MOST 106-2320-B-182A-003- | Corylin Suppresses Hepatocellular Carcinoma Progression via the Inhibition of Epithelial-Mesenchymal Transition, Mediated by Long Noncoding RNA GAS5 | SCI, SSCI | 第八作者 | 是 | International Journal of Molecular Sciences | 19 | 2 | 01 | 2018 |
106 | CRRPG3F0071 | Application of ribonucleoside vanadyl complex (RVC) for developing a multifunctional tissue preservative solution | SCI, SSCI | 第六作者 | 是 | PLoS ONE | 13 | 3 | 03 | 2018 |
106 | MOST 106-2320-B-182A-003- | Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair | SCI, SSCI | 第八作者 | 是 | Cell Death & Disease | 9 | 5 | 05 | 2018 |
107 | CMRPG3G0941 | Melatonin Inhibits the Progression of Hepatocellular Carcinoma through MicroRNA Let7i-3p Mediated RAF1 Reduction | SCI, SSCI | 第一作者 | 否 | International Journal of Molecular Sciences | 19 | 9 | 09 | 2018 |
107 | CRRPG3F0072 | Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair | SCI, SSCI | 第九作者 | 是 | Cancers | 10 | 9 | 09 | 2018 |
107 | MOST106-2320-B-182-018 | Low PD-L1 Expression Strongly Correlates with Local Recurrence in Epstein-Barr Virus-Positive Nasopharyngeal Carcinoma after Radiation-Based Therapy | SCI, SSCI | 第六作者 | 否 | Cancers | 10 | 10 | 10 | 2018 |
107 | CMRPF1E0023 | 2-O-Methylmagnolol Induces Apoptosis and Inhibits IL-6/STAT3 Signaling in Oral Squamous Cell Carcinoma | SCI, SSCI | 第一作者 | 否 | Cellular Physiology and Biochemistry | 50 | 3 | 10 | 2018 |
106 | CMRPF1G0121 | Heterogeneous Nuclear Ribonucleoproteins A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres | SCI, SSCI | 第一作者 | 否 | Cancers | 11 | 3 | 03 | 2018 |
107 | MOST 106-2320-B-255-006 | Heterogeneous Nuclear Ribonucleoproteins A1 and A2 Function in Telomerase-Dependent Maintenance of Telomeres | SCI | 第一作者 | 否 | Cancers | 11 | 3 | 03 | 2019 |
107 | CMRPF1H0011 | High levels of EGFR prevent sulforaphane-induced reactive oxygen species-mediated apoptosis in non-small-cell lung cancer cells | SCI | 第一作者 | 否 | Phytomedicine | 64 | 64 | 04 | 2019 |
107 | 無 | Oral Submucous Fibrosis: A Review on Etiopathogenesis, Diagnosis, and Therapy | SCI | 第一作者 | 否 | International Journal of Molecular Sciences | 20 | 12 | 06 | 2019 |
108 | 無 | A novel DNA repair inhibitor, diallyl disulfide (DADS), impairs DNA resection during DNA double-strand break repair by reducing Sae2 and Exo1 levels | SCI | 第三作者 | 否 | DNA Repair | 82 | 0 | 08 | 2019 |
108 | 無 | Dietary Compound Isoliquiritigenin, an Antioxidant from Licorice, Suppresses Triple-Negative Breast Tumor Growth via Apoptotic Death Program Activation in Cell and Xenograft Animal Models | SCI | 第六作者 | 否 | Antioxidants | 9 | 3 | 03 | 2020 |
108 | CMRPG3H1001 | Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells | SCI | 第八作者 | 是 | Frontiers in Oncology | 10 | 10 | 02 | 2020 |
108 | 無 | Successful Identification of Nasopharyngeal Carcinoma in Nasopharyngeal Biopsies Using Deep Learning | SCI | 第十一作者以上 | 否 | Cancers | 12 | 2 | 02 | 2020 |
108 | CMRPF1I0011 | Hydroxygenkwanin Suppresses Non-Small Cell Lung Cancer Progression by Enhancing EGFR Degradation | SCI | 第一作者 | 否 | Molecules | 25 | 4 | 02 | 2020 |
108 | 無 | Night time resistance exercise alters muscular IL-6-related protein signaling, but not muscle growth after 10 weeks of resistance training in male rats | SCI | 第四作者 | 否 | General Physiology and Biophysics | 39 | 1 | 01 | 2020 |
108 | 無 | Suppression of Hepatocellular Carcinoma Progression through FOXM1 and EMT Inhibition via Hydroxygenkwanin-Induced miR-320a Expression | SCI | 第八作者 | 是 | Biomolecules | 10 | 1 | 12 | 2019 |
108 | 無 | Psorachromene Suppresses Oral Squamous Cell Carcinoma Progression by Inhibiting Long Non-coding RNA GAS5 Mediated Epithelial-Mesenchymal Transition | SCI | 第一作者 | 否 | Frontiers in Oncology | 9 | 9 | 11 | 2019 |
108 | 無 | Identification of CD5/Cyclin D1 Double-negative Pleomorphic Mantle Cell Lymphoma: A Clinicopathologic, Genetic, and Gene Expression Study | SCI | 第九作者 | 否 | The American Journal of Surgical Pathology | 44 | 2 | 02 | 2020 |
108 | MOST 108-2320-B-182-030-MY3 | Profiling of subcellular EGFR interactome reveals hnRNP A3 modulates nuclear EGFR localization | SCI | 第一作者 | 否 | Oncogenesis | 9 | 4 | 04 | 2020 |
109 | MOST 107-2314-B-182A-140-MY3 | 2-O-Methylmagnolol, a Magnolol Derivative, Suppresses Hepatocellular Carcinoma Progression via Inhibiting Class I Histone Deacetylase Expression | SCI | 第十作者 | 是 | Frontiers in oncology | 10 | 0 | 08 | 2020 |
109 | 無 | Effects of melatonin to arecoline-induced reactive oxygen species production and DNA damage in oral squamous cell carcinoma | SCI | 第三作者 | 否 | Journal of the Formosan Medical Association | 120 | 1 | 01 | 2021 |
109 | 無 | In vitro antimicrobial and antipro-inflammation potential of honokiol and magnolol against oral pathogens and macrophages | SCI | 第三作者 | 否 | Journal of the Formosan Medical Association | 120 | 2 | 02 | 2021 |
109 | 無 | Antimetabolite pemetrexed primes a favorable tumor microenvironment for immune checkpoint blockade therapy | SCI | 第八作者 | 否 | Journal for ImmunoTherapy of Cancer | 8 | 2 | 11 | 2020 |
109 | CMRPG3J0862 | Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma | SCI | 第一作者 | 否 | Journal of the Formosan Medical Association | 0 | 0 | 12 | 2020 |
109 | CMRPF3L0011 | Integrated Omics Analysis of Non-Small-Cell Lung Cancer Cells Harboring the EGFR C797S Mutation Reveals the Potential of AXL as a Novel Therapeutic Target in TKI-Resistant Lung Cancer | SCI | 第一作者 | 否 | Cancers | 13 | 1 | 12 | 2020 |
109 | 無 | Integrated Omics Analysis of Non-Small-Cell Lung Cancer Cells Harboring the EGFR C797S Mutation Reveals the Potential of AXL as a Novel Therapeutic Target in TKIResistant Lung Cancer | SCI | 第一作者 | 否 | Cancers | 13 | 1 | 01 | 2021 |
109 | 無 | Biofilm Formation on the Surface of (Poly)Ether-Ether-Ketone and In Vitro Antimicrobial Efficacy of Photodynamic Therapy on Peri-Implant Mucositis | SCI | 第八作者 | 否 | Polymers | 13 | 6 | 03 | 2021 |
109 | 無 | Plasma interleukin-17 and alpha-fetoprotein combination effectively predicts imminent hepatocellular carcinoma occurrence in liver cirrhotic patients | SCI | 第八作者 | 否 | BMC GASTROENTEROLOGY | 21 | 1 | 04 | 2021 |
110 | CMRPF1H0013 | Growth Suppression in Lung Cancer Cells Harboring EGFR-C797S Mutation by Quercetin | SCI | 第一作者 | 否 | Biomolecules | 11 | 9 | 08 | 2021 |
110 | 無 | In Vitro Assessment of the Cell Metabolic Activity, Cytotoxicity, Cell Attachment, and Inflammatory Reaction of Human Oral Fibroblasts on Polyetheretherketone (PEEK) Implant-Abutment | SCI | 第四作者 | 否 | Polymers | 13 | 17 | 09 | 2021 |
110 | CMRPG3H1003 | Hydroxygenkwanin Increases the Sensitivity of Liver Cancer Cells to Chemotherapy by Inhibiting DNA Damage Response in Mouse Xenograft Models | SCI | 第十一作者以上 | 是 | International journal of molecular sciences | 22 | 18 | 09 | 2021 |
110 | 無 | Identification of nodal micrometastasis in colorectal cancer using deep learning on annotation-free whole-slide images | SCI | 第七作者 | 否 | Modern Pathology | 34 | 10 | 10 | 2021 |
110 | CMRPG3J086 | Palbociclib induces DNA damage and inhibits DNA repair to induce cellular senescence and apoptosis in oral squamous cell carcinoma | SCI | 第一作者 | 否 | Journal of the formosan medical association | 120 | 9 | 09 | 2021 |
110 | 無 | The relation between NEAT1 expression level and survival rate in patients with oral squamous cell carcinoma | SCI | 第二作者 | 否 | Journal of Dental Sciences | 17 | 1 | 01 | 2022 |
110 | CMRPD1K0381 | The flavonoid corylin exhibits lifespan extension properties in mouse | SCI | 第一作者 | 否 | Nature Communications | 13 | 1 | 03 | 2022 |
110 | 無 | Psorachromene induces apoptosis and suppresses tumor growth in NSCLC cells harboring EGFR L858R/T790M/C797S | SCI | 第一作者 | 否 | Phytotherapy Research | 36 | 5 | 05 | 2022 |
111 | 無 | Deep Learning-Based Nuclear Morphometry Reveals an Independent Prognostic Factor in Mantle Cell Lymphoma | SCI | 第十一作者以上 | 否 | American Journal of Pathology | 192 | 12 | 12 | 2022 |
111 | 無 | Effects of Temoporfin-Based Photodynamic Therapy on the In Vitro Antibacterial Activity and Biocompatibility of Gelatin-Hyaluronic Acid Cross-Linked Hydrogel Membranes | SCI | 第六作者 | 否 | Pharmaceutics | 14 | 11 | 10 | 2022 |
111 | 無 | Association of rs9679162 Genetic Polymorphism and Aberrant Expression of Polypeptide N-Acetylgalactosaminyltransferase 14 (GALNT14) in Head and Neck Cancer | SCI | 第七作者 | 否 | Cancers | 14 | 17 | 08 | 2022 |
110 | 無 | In Vitro Antimicrobial Potential of CAPE and Caffeamide Derivatives against Oral Microbes | SCI | 第三作者 | 否 | International Journal of Molecular Sciences | 23 | 8 | 04 | 2022 |
111 | 無 | Caffeic Acid Phenethyl Ester and Caffeamide Derivatives Suppress Oral Squamous Cell Carcinoma Cells | SCI, SSCI | 第六作者 | 否 | International Journal of Molecular Sciences | 24 | 12 | 06 | 2023 |
111 | 無 | PM2.5 promotes lung cancer progression through activation of the AhR-TMPRSS2-IL18 pathway | SCI, SSCI | 第一作者 | 否 | EMBO Molecular Medicine | 15 | 6 | 06 | 2023 |
112 | 112-2320-B-182A-009-MY3 | Corylin Attenuates CCl4-Induced Liver Fibrosis in Mice by Regulating the GAS6/AXL Signaling Pathway in Hepatic Stellate Cells | SCI, SSCI | 第十作者 | 是 | International Journal of Molecular Sciences | 24 | 23 | 11 | 2023 |
研討會論文列表
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年度 | 所屬計畫案 | 論文名稱 | 作者順序 | 通訊作者 | 研討會名稱 | 舉行國家 | 舉行城市 | 開始日期 | 結束日期 | 發表年份 |
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發表專書列表
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年度 | 所屬計畫案 | 專書類別 | 專書名稱 | 作者順序 | 通訊作者 | 使用語文 | 出版日期 | 出版社 | ISBN編號 |
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專利/新品種列表
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年度 | 所屬計畫案 | 專利/新品種名稱 | 區域 | 類型 | 作者順序 |
106 | MOST 104-2320-B-182A-009 | 用於預測一帶有一癌症的人類個體的存活時間的方法 | 國內 | 發明專利 | 第一作者 |
108 | 使用2,4-二甲氧基-6-甲基苯-1,3-二醇來治療異位性皮膚炎 | 國內 | 發明專利 | 第一作者 | |
108 | 使用2,4-二甲氧基-6-甲基苯-1,3-二醇來防止和/或抑制葡萄球菌屬物種的生長以及生物膜形成 | 國內 | 發明專利 | 第一作者 | |
109 | MOST 106-2320-B-182A-003 | 使用2,4-二甲氧基-6-甲基苯-1,3-二醇來預防和/或治療乾癬 | 國內 | 發明專利 | 第一作者 |
獲頒獎項與榮譽列表
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年度 | 所屬計畫案 | 名稱 | 國別 | 機構名稱 | 日期 |
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教師技術移轉或授權列表
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學年度 | 技術移轉或授權 | 技轉或授權名稱 | 技術移轉或授權廠商名稱 | 技術移轉金額或授權金額 | 技術移轉或授權起始日期 | 技術移轉或授權終止日期 | 技術移轉或授權合約編號 | 是否取得專利 | 專利證書字號 |
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